XTANDI is a prescription medicine used to treat men with prostate cancer that:

  • no longer responds to a hormone therapy or surgical treatment to lower testosterone
  • OR

  • has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

It is not known if XTANDI is safe and effective in females or children.

XTANDI frequently asked questions

You may have questions about XTANDI. Scroll down to find the answers to some frequently asked questions.

What is the generic name for XTANDI?

The generic name for XTANDI is enzalutamide.

What is XTANDI (enzalutamide)?

XTANDI is a prescription medicine used to treat men with prostate cancer that:

  • No longer responds to a hormone therapy or surgical treatment to lower testosterone
  • OR

  • Has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

It is not known if XTANDI is safe and effective in females or children. See how XTANDI may help.

What types of prostate cancer does XTANDI treat?

XTANDI is a prescription medicine that is FDA‑approved to treat 3 types of prostate cancer:

  • Metastatic castration‑sensitive prostate cancer (mCSPC): prostate cancer that has spread to other parts of the body and responds to treatment to lower testosterone. Learn more about mCSPC.
  • Metastatic castration‑resistant prostate cancer (mCRPC): prostate cancer that has spread to other parts of the body and no longer responds to treatment to lower testosterone. Learn more about mCRPC.
  • Non‑metastatic castration‑resistant prostate cancer (nmCRPC): prostate cancer that has not spread to other parts of the body and no longer responds to treatment to lower testosterone. Learn more about nmCSPC.

How does XTANDI work?

XTANDI is an androgen receptor inhibitor. Androgens are a group of hormones that includes testosterone. Androgen receptor inhibitors interfere with the connection between androgens and androgen receptors. This can help slow cancer cell growth. See how XTANDI works.

What are androgen receptor inhibitors?

Androgen receptor inhibitors (also called antiandrogens or androgen receptor antagonists) are a class of drugs that are used to help keep prostate cancer cells from growing. They act by inhibiting androgen hormones, such as testosterone. See how XTANDI works.

Is XTANDI a form of chemotherapy?

XTANDI is an androgen receptor inhibitor; it is not a chemotherapy. Androgens are a group of hormones that includes testosterone. Androgen receptor inhibitors interfere with the connection between androgens and androgen receptors. This can help slow cancer cell growth. See how XTANDI works.

What is the dosing and administration for XTANDI?

XTANDI is taken by mouth and is available in 2 dosage strengths: 40 mg and 80 mg.

Take XTANDI once a day, at the same time every day, with or without food. See how to take XTANDI.

What are the key differences between XTANDI tablets and XTANDI capsules?

XTANDI comes in both capsule and tablet formulations. Capsules are available in 40 mg capsules only. Smaller‑sized tablets are available in 2 dosage strengths: 40 mg and 80 mg tablets, giving you more options to meet your daily dose.

The recommended dose of XTANDI is 160 mg, taken once a day. However, your prescribed dosage may vary.

XTANDI tablets are animal‑free and do not contain gelatin.

XTANDI® (enzalutamide) capsule and tablet doses

How do I take XTANDI?

Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. Your doctor may change your dose if needed. See how to take XTANDI.

Do I need to take XTANDI with food?

XTANDI can be taken with or without food. See how to take XTANDI.

What are the most common side effects of XTANDI?

The most common side effects of XTANDI include:

  • Weakness or feeling more tired than usual
  • Back pain
  • Hot flashes
  • Constipation
  • Joint pain
  • Decreased appetite
  • Diarrhea
  • High blood pressure

It is not known if XTANDI is safe and effective in females or children. See how XTANDI may help.

How do I get XTANDI?

XTANDI is a prescription medicine that you can get through a specialty pharmacy or the pharmacy in your doctor’s office. Find out how to get XTANDI.

Are there ways to help pay for XTANDI?

XTANDI tablets cost the same as XTANDI capsules. If you need help paying for XTANDI, call XTANDI Support Solutions® at 1‑855‑8XTANDI (1‑855‑898‑2634) to speak to an access specialist who may help you find ways to pay for XTANDI. Learn more about XTANDI support solutions.

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