Real patients.
Real stories.

JIM: Who wants to ride with me? Anybody?

JIM'S FRIEND: I'll ride with you.

JIM: Okay, alright. I'm a positive person. I'll throw my heart across the bar and then jump. All right, you ready? There's always setbacks in life. And if there's an issue, I face it head-on.

JIM'S FRIEND: Man, look at that. Oh, good swing there. Yeah, man.

JIM: Right down the middle, boys.

JIM'S FRIEND: Nice.

JIM: Thank you, my man.

JIM'S FRIEND: Well done.

JIM: My name is Jim, and I live in South Carolina.

BETH: Water.

JIM: Thank you, darling. I appreciate that.

I was a cheerleader here at school. It taught me to keep a positive attitude no matter what the score is and when you're with people, that positivity comes out on them as well. To many more rounds. To many more birdies.

I worked in sales for 40 years. Since then, I moved back home to my alma mater. And it's just something about living in a college town that makes you feel young. I love to fish, I love to hunt, I love to play golf.

JIM'S FRIEND: Go in the hole. Yes sir!

JIM: I like the saying, "Don't let the old man in." You got to keep moving in life because once you stop, it's not any fun anymore.

You know, I've always tried to take care of my health. Ran a lot of 10Ks, ran six marathons. The only thing that ever kept coming up was my cholesterol. This just kind of focused in on my blood work and everything on it. And my doctor said, "I don't like where your PSA is. We need to do something about this." And so we scheduled a biopsy. When I walked in for the results, I could tell by the look on my doctor's face that something was not right.

And he said, "I've got bad news." I said, "What is that?" "You have prostate cancer." My head's spinning. I'm thinking, "Okay, where do we go? What do we do? I'm way ahead of my skis on this." I called my wife. I said, "Honey, I've got cancer." So there's a pause, and she said, "Well, what are you going to do?" I said, "I'm going hunting."

That's my happy place. And when I get back, we will formulate a plan.

After my diagnosis, I kind of looked back over my life, took a deep breath, and I said, "You're a cheerleader. You're positive. Be positive you will do something about it." I came up with a lot of questions for the oncologist, and at the end I said, "If you were me, what would you do?" He said, "I would have it removed." And so that's what I did.

And then we started on this journey of meeting with my doctor every six months and monitoring my numbers and the numbers were great. The cancer had not spread.

Four years later, my doctor and I noticed my PSA was starting to go up again and I remember thinking like, "Okay, what do we do now?" I was really worried when those numbers started going back up and I went through those radiation treatments. It was tough, but we got it done and I couldn't wait to get my numbers. Numbers hadn't changed very much. And then my PSA doubled in less than a year. And I'm like, "Darn, this thing is tough."

My doctor told me that even though I had prostate removal surgery and radiation, my rising PSA was still an indicator that I was at high risk of my cancer spreading. Just when I thought I was succeeding, it kicked me in the gut again, and I was saying, "What do we do next? Where do we go?"

That's when my doctor told me about a clinical trial for XTANDI (enzalutamide), which was already approved for other types of advanced prostate cancer. And that I was an excellent candidate based on my rapidly rising PSA.

ANNOUNCER: You're about to hear some information about XTANDI. Stay tuned for the rest of Jim's story.

What is XTANDI?

XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children.

Please listen to the safety information about XTANDI during this video and see additional safety information and Full Prescribing Information on the XTANDI website.

JIM: While I knew XTANDI was already approved for other types of advanced prostate cancer, I still researched the potential side effects. My doctor said the most common side effects include hot flashes, fatigue, and muscle and joint pain. As part of my treatment, I take XTANDI as well as androgen deprivation therapy, also known as ADT. In addition, I get my PSA checked every six months.

ANNOUNCER: Important Safety Information. Talk to your doctor or go to the emergency room right away if you experience any of these serious side effects while on XTANDI, including:

• Seizure or Sudden Loss of Consciousness. Avoid activities where loss of consciousness could cause serious harm to yourself or others.
• Posterior Reversible Encephalopathy Syndrome (PRES), a brain condition, may develop. Includes seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will check for PRES.
• Allergic Reactions. Stop taking XTANDI if you develop swelling of the face, tongue, lip or throat.
• Ischemic Heart Disease, the blockage of arteries in the heart that can lead to death. Symptoms include: chest pain, discomfort at rest or with activity, and shortness of breath. Your doctor will monitor you for signs of this disease during your treatment.
• Increased Risk of Falls and Bone Fractures. Falls were not caused by loss of consciousness (fainting) or seizures.
• Swallowing Problems or Choking. Life-threatening problems or death can happen in people during treatment because of the size of the XTANDI capsules and tablets. Swallow each capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will monitor your risks and stop XTANDI if you have serious side effects. Additional safety information can be found later in this video.

JIM: My initial thoughts of XTANDI was that having a pill every day fit in my lifestyle. I could do it at home. I take them at night and I have a routine that I don't miss a day.

I'm very fortunate that XTANDI treats my type of advanced prostate cancer. My doctor and I continue to be pleased with my results.

What do you think, Scar? That's my girl.

When you have prostate cancer and you get your blood work done, you need to know your numbers. You know about one in eight men are going to have prostate cancer.

Why is it that men don't want to get a PSA check?

JIM'S FRIEND: I think historically men don't really like to go to doctors.

JIM: With PSA you have a baseline. If it rises or doubles, you need to talk to your doctor. You know, I've known my urologist for 14 years. Once we finish talking about my numbers, we start talking about football.

When you're looking for a urologist, find someone that takes the time, that looks beyond your condition and will take that interest in you to learn what is going on in your life and what emotions you are feeling at that moment.

Here's some helpful questions you might want to ask your doctor.

• What changes in my numbers would indicate my prostate cancer is starting to spread or has returned?
• If it does spread, what are my options?
• If my PSA is rising, or doubles, what are my next steps?
• What procedures or treatments are available to me?
• Is XTANDI right for me?

Whatever you do, don't change who you are because you have prostate cancer. Keep being you. But do live a healthy lifestyle. Follow your doctor's advice, walk, run, do whatever you can to stay active. To this day, I continue to be my own best advocate and I encourage you to do the same.

I was my own cheerleader. My head was never down. I said, let's go. Let's go. Let's get this journey on and let's cheer each other on. And the main thing is we celebrate each other. I'm just so blessed that I have been able to have this opportunity to live my life and not let the old man in.

JIM'S FRIEND: Well Jim, you've educated us and we thank you for that.

JIM: I have a mission in life now. To talk and tell other men, "You're not there alone." That's why I'm sitting here. You've seen me play golf. You've seen me walk my dogs. You've seen me hold my chicken. You've seen my loving wife. Don't take life for granted. It's a gift. Every morning, every night, every day that you wake up. There are other men here. There are doctors here that are going to help you along the way.

JIM'S FRIEND: Yeah, baby. Yes, sir.

JIM: We're in this together.

ANNOUNCER: Important Safety Information & Use About XTANDI.

What should I tell my doctor before taking XTANDI?

Tell your doctor about all your medical conditions, including if you:

• Have a history of seizures, brain injury, stroke, or brain tumors.
• Have a history of heart disease, have high blood pressure, or have abnormal amounts of fat or cholesterol in your blood (dyslipidemia).
• Are pregnant or plan to become pregnant. XTANDI can cause harm to your unborn baby and loss of pregnancy (miscarriage).
• Have a partner who is pregnant or may become pregnant.
  • Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with XTANDI and for 3 months after the last dose.
  • Males must use a condom during sex with a pregnant female.
• Are breastfeeding or plan to breastfeed. It is not known if XTANDI passes into your breast milk.
• Take other medicines. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. These include prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop any medicine without talking to your doctor.

How should I take XTANDI?

• Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. XTANDI can be taken with or without food. Swallow XTANDI capsules or tablets whole with enough water to make sure that you can swallow all of the medicine successfully. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets. Your doctor may change your dose if needed. Your doctor may also change your pill size or stop treatment if you have swallowing problems.
• Do not change or stop taking your prescribed dose of XTANDI without talking with your doctor first.
• If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment while taking XTANDI unless you have had surgery to lower the amount of testosterone in your body (surgical castration).
• If you miss a dose of XTANDI: Take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI each day.
• If you take too much XTANDI: Call your doctor or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

• Seizure. If you take XTANDI, you may be at risk of having a seizure. Avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your doctor right away if you lose consciousness or have a seizure.
• Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your doctor right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will do a test to check for PRES.
• Allergic Reactions. Allergic reactions have happened in people who take XTANDI. Stop taking XTANDI and get medical help right away if you develop swelling of the face, tongue, lip or throat.
• Heart Disease. Blockage of the arteries in the heart (ischemic heart disease) that can lead to death has happened in some people during treatment with XTANDI. Your doctor will monitor you for signs and symptoms of heart problems during your treatment. Call your doctor or go to the emergency room right away if you get chest pain or discomfort at rest or with activity or shortness of breath during your treatment with XTANDI.
• Falls and Bone Fractures. XTANDI treatment may increase your risk for falls and bone fractures. Falls were not caused by loss of consciousness or seizures. Your doctor will monitor your risks for falls and bone fractures during treatment with XTANDI.
• Swallowing Problems or Choking. Severe swallowing problems or choking, including life-threatening problems or death can happen in people during treatment with XTANDI, because of the size of the XTANDI capsules and tablets. Swallow each XTANDI capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will stop treatment with XTANDI if you have serious side effects.

The most common side effects of XTANDI include:

• Muscle and joint pain
• Feeling more tired than usual
• Hot flashes
• Constipation
• Decreased appetite
• Diarrhea
• High blood pressure
• Bleeding problems
• Falls
• Bone fractures
• Headache

XTANDI may cause fertility problems in males, which may affect the ability to father children. Talk to your doctor if you have concerns about fertility.

These are not all the possible side effects of XTANDI. For more information, talk to your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For further information, please talk to your doctor and read the Patient Information and Full Prescribing Information for XTANDI.

What is XTANDI?

XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children.

EUVON: I know, I know, my man on the drums been playing forever. I know you have man.

I grew up with a little toy guitar in my hand. I always just loved music. Music is what the heart sounds like. And I didn't realize where it would take me. Once I got to high school, I became a part of a cover band and we toured up and down the East Coast. There would be times I would be on stage and have these out-of-body experiences. It was such a blast.

But the number one thing that music brought me is my lovely, beautiful wife.

My name is Euvon.

JANET: I'm Janet. I'm Euvon's wife.

EUVON: Very thankful for meeting Janet, having kids.

EUVON: Our lives were great.

But when I turned 59 years old, I was in a swimming pool. I had this young boy and we raced three times. The first time I beat him, the second time he beat me. And the third time I became like a shark. And I wiped him off almost the face of the earth.

Well, that Monday, I couldn't get out of bed. I had so much pain in my body. I couldn't. I couldn't even. I couldn't even walk.

I didn't know where that pain was coming from, and so after one thing led to another, I got diagnosed with metastatic prostate cancer, which had a PSA that was very high.

The experience of having prostate cancer is that you realize that you are in a club that you never signed up for.

My dad never died from prostate cancer, but he had it. My uncle had it. I was so afraid. I didn't know who to talk to, what to talk about it...

BANDMATE #1: ...because we don't open up all that easily.

EUVON: Men don't like to talk about themselves and they hate talking about prostate cancer. I didn't know if I was being proud or if I was being honest.

There's a lot to be said about the demographics of prostate cancer, and there's a lot of information around Black men getting prostate cancer at higher rates.

BANDMATE #2: You're young. You never think about how you're going to develop things as you get older. Prostate cancer has taken a lot of men out because they are afraid to go get examined.

EUVON: We're not going to doctors enough. And also, there are trust issues, but you know what? I sure trust doctors now.

As a man, after you receive that diagnosis, you have to own it and then you have to study it. The other thing you have to do is to be open to accepting help.

JANET: One of the most important things that I wanted to do was to get him to continue to communicate. I told my husband, "This is not your disease. This is not your battle. This is our battle. And we're going to fight this formidable foe." So I became a student of his diagnosis.

EUVON: My oncologist and I worked together. She told me about XTANDI, also known as enzalutamide, and we got to work.

ANNOUNCER: You're about to hear some information about XTANDI. Stay tuned for the rest of Euvon's story.

What is XTANDI?

XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children.

Please listen to the safety information about XTANDI during this video and see additional safety information and Full Prescribing Information on the XTANDI website.

EUVON: My oncologist and I worked together to choose XTANDI because of its clinical trials.

It helped some patients delay the progression of their cancer and also live longer.

We also talked about key safety information and possibility of some side effects, including back pain and even feeling more tired than usual.

ANNOUNCER: Important Safety Information

Talk to your doctor or go to the emergency room right away if you experience any of these serious side effects while on XTANDI, including:

• Seizure or Sudden Loss of Consciousness. Avoid activities where loss of consciousness could cause serious harm to yourself or others.
• Posterior Reversible Encephalopathy Syndrome (PRES), a brain condition, may develop. Includes seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will check for PRES.
• Allergic Reactions. Stop taking XTANDI if you develop swelling of the face, tongue, lip or throat.
• Ischemic Heart Disease, the blockage of arteries in the heart that can lead to death. Symptoms include: chest pain, discomfort at rest or with activity, and shortness of breath. Your doctor will monitor you for signs of this disease during your treatment.
• Increased Risk of Falls and Bone Fractures. Falls were not caused by loss of consciousness (fainting) or seizures.
• Swallowing Problems or Choking. Life-threatening problems or death can happen in people during treatment because of the size of the XTANDI capsules and tablets. Swallow each capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will monitor your risks and stop XTANDI if you have serious side effects. Additional safety information can be found later in this video.

EUVON: These are all the people that are trying to keep me healthy. When you have prostate cancer support is such a powerful thing. The relationship we have had with my oncologist has gone from doctor to more of a family member.

From being open with her we have developed a high level of trust.

JANET: We turned his diagnosis into a battle of triumph. And it even strengthened our marriage, strengthened our relationship with our family and our friends.

EUVON: Community is important because you don't even realize until you open up. You're not alone.

BANDMATE #1: We've made music together more times since this cancer journey of yours than in the 10 years before.

JANET: Throughout this entire experience, our children have been a godsend.

EUVON: They all came together to be our army for many of the treatments I received.

JANET: They were very strong and they were encouraging and they lifted me up. They helped get me out of my darkness. And so that encouraged me. And in turn, it encouraged him.

EUVON: Once you get over the shock of diagnosis and you start to make your game plan, realize that for however long that you're here, you've got something to do. It's not only about you. I think we can be a lot better if we were truly honest with our families and our doctors. Prostate cancer will challenge you. And intimacy is a part of that. But my oncologist said something to me that stuck with me forever, she said, "A mind is a terrible thing to waste." And I said, "Doctor, you are so right about that."

XTANDI has many other helpful resources. They put XTANDI patients in contact with the people in charge of financial assistance. XTANDI also has many other helpful resources, such as a doctor's discussion guide. To get it, all you have to do is go to XTANDI.com. So get involved in your own health.

You're not alone. Fighting cancer is a team effort. Learn from my experience. Don't wait to talk to your doctor. Talk early. You're not alone.

ANNOUNCER: What is XTANDI?

XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children.

Important Safety Information

What should I tell my doctor before taking XTANDI?

Tell your doctor about all your medical conditions, including if you:

• Have a history of seizures, brain injury, stroke, or brain tumors.
• Have a history of heart disease, have high blood pressure, or have abnormal amounts of fat or cholesterol in your blood (dyslipidemia).
• Are pregnant or plan to become pregnant. XTANDI can cause harm to your unborn baby and loss of pregnancy (miscarriage).
• Have a partner who is pregnant or may become pregnant.
  • Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with XTANDI and for 3 months after the last dose.
  • Males must use a condom during sex with a pregnant female.
• Are breastfeeding or plan to breastfeed. It is not known if XTANDI passes into your breast milk.
• Take other medicines. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. These include prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop any medicine without talking to your doctor.

How should I take XTANDI?

• Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. XTANDI can be taken with or without food. Swallow XTANDI capsules or tablets whole with enough water to make sure that you can swallow all of the medicine successfully. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets. Your doctor may change your dose if needed. Your doctor may also change your pill size or stop treatment if you have swallowing problems.
• Do not change or stop taking your prescribed dose of XTANDI without talking with your doctor first.
• If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment while taking XTANDI unless you have had surgery to lower the amount of testosterone in your body (surgical castration).
• If you miss a dose of XTANDI: Take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI each day.
• If you take too much XTANDI: Call your doctor or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

• Seizure. If you take XTANDI, you may be at risk of having a seizure. Avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your doctor right away if you lose consciousness or have a seizure.
• Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your doctor right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will do a test to check for PRES.
• Allergic Reactions. Allergic reactions have happened in people who take XTANDI. Stop taking XTANDI and get medical help right away if you develop swelling of the face, tongue, lip or throat.
• Heart Disease. Blockage of the arteries in the heart (ischemic heart disease) that can lead to death has happened in some people during treatment with XTANDI. Your doctor will monitor you for signs and symptoms of heart problems during your treatment. Call your doctor or go to the emergency room right away if you get chest pain or discomfort at rest or with activity or shortness of breath during your treatment with XTANDI.
• Falls and Bone Fractures. XTANDI treatment may increase your risk for falls and bone fractures. Falls were not caused by loss of consciousness or seizures. Your doctor will monitor your risks for falls and bone fractures during treatment with XTANDI.
• Swallowing Problems or Choking. Severe swallowing problems or choking, including life-threatening problems or death can happen in people during treatment with XTANDI, because of the size of the XTANDI capsules and tablets. Swallow each XTANDI capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will stop treatment with XTANDI if you have serious side effects.

The most common side effects of XTANDI include:

• Muscle and joint pain
• Feeling more tired than usual
• Hot flashes
• Constipation
• Decreased appetite
• Diarrhea
• High blood pressure
• Bleeding problems
• Falls
• Bone fractures
• Headache

XTANDI may cause fertility problems in males, which may affect the ability to father children. Talk to your doctor if you have concerns about fertility.

These are not all the possible side effects of XTANDI. For more information, talk to your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For further information, please talk to your doctor and read the Patient Information and Full Prescribing Information for XTANDI.

HENRY: For me, everything starts with an idea. I like inventing because I went to school to be a scientist.

I ended up becoming a material scientist and there's so many options out there for, you know, applying my trade, applying my knowledge, applying my skills.

I like creating things, not just for the sake of creating things, I'm the guy who realizes that when I come up with a new idea, it means jobs for people. That's what, like, drives me.

When I got my diagnosis of advanced prostate cancer, I knew I needed to get through this... one piece at a time.

One day after going on an extended run, I woke up the next morning with severe lower back pain. Initially I was just chalking it up to another ache and pain of old age, but it didn't subside. And after about three or four days, I called my primary care physician. So, he prescribed 20 sessions with a physical therapist. And that didn't solve the problem either.

Then I was noticing some problems with my urination. I was hardly able to pee at all.

Then I took these symptoms back to my doctor, and he referred me to a urologist. My urologist did some blood work and came back with some tough news. My prostate-specific antigen, or PSA levels, was the highest that he had ever seen. He let me know that high PSA levels can be a sign of prostate cancer. So, we moved quickly to schedule a biopsy and CT scans.

When the results came back, I was diagnosed with metastatic castration-sensitive prostate cancer or mCSPC. That means that the prostate cancer has spread to other parts of the body and responds to hormone therapy or surgical treatment to lower testosterone.

I was devastated.

I've lived a good life, but those first two months were the worst two months of my life. I worried about how much of my life I was going to miss—my daughters' two weddings, how to care for my wife in my absence. Like, I didn't know if I had three months, six months, nine months, three years, three decades.

I really had some crazy thoughts going on in my head.

My life as I knew it just went out the window, and my wife Catherine really helped pull me out of my depressive state. We decided together that we weren't going to just roll over and let this diagnosis dictate our lives.

We were going to search for answers one piece at a time.

We were very open about my diagnosis with our family and friends. The outpouring from my support community was incredible. Well, when you get this response from your support network, you realize that there's a lot of people that love you and a lot of people that depend on you. So, it's not just about you anymore.

I was going to fight hard anyway, but now I've got a thousand reasons to fight even harder.

Just like in my career as a material scientist, this meant breaking the problem down and approaching it one step at a time. I turn to social media prostate cancer support groups to learn as much as I can about treatment for prostate cancer. Yeah, it was great not only to find a community that understood where I was, but they empathized with where I was.

I switched my care to a leading cancer treatment center. My new doctor treated Katherine and I as partners in coming up with a treatment plan that would work for me, which included XTANDI, also known as enzalutamide, a treatment that has shown outcomes for men like me in clinical studies, and it's been prescribed to over 300,000 patients with advanced prostate cancer.

ANNOUNCER: XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children.

Important Safety Information

XTANDI may cause serious side effects, including seizure, posterior reversible encephalopathy syndrome (PRES), allergic reactions, heart disease, falls and bone fractures, and swallowing problems or choking.

You will learn more about these and other side effects later in the video.

HENRY: My doctor talked to us about the most common side effects of XTANDI, including muscle and joint pain, feeling more tired than usual, hot flashes, and constipation. After going over the risks and benefits of XTANDI, we decided to give it a try. XTANDI is a tablet, so it'd fit into my daily routine. I was excited about my treatment and what it could mean for our future. I do experience side effects such as fatigue and joint pain. But I work with my doctor to help manage them.

ANNOUNCER: What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

• Seizure. If you take XTANDI, you may be at risk of having a seizure. Avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your doctor right away if you lose consciousness or have a seizure.
• Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your doctor right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will do a test to check for PRES.
• Allergic Reactions. Allergic reactions have happened in people who take XTANDI. Stop taking XTANDI and get medical help right away if you develop swelling of the face, tongue, lip or throat.
• Heart Disease. Blockage of the arteries in the heart (ischemic heart disease) that can lead to death has happened in some people during treatment with XTANDI. Your doctor will monitor you for signs and symptoms of heart problems during your treatment. Call your doctor or go to the emergency room right away if you get chest pain or discomfort at rest or with activity or shortness of breath during your treatment with XTANDI.
• Falls and Bone Fractures. XTANDI treatment may increase your risk for falls and bone fractures. Falls were not caused by loss of consciousness or seizures. Your doctor will monitor your risks for falls and bone fractures during treatment with XTANDI.
• Swallowing Problems or Choking. Severe swallowing problems or choking, including life-threatening problems or death can happen in people during treatment with XTANDI, because of the size of the XTANDI capsules and tablets. Swallow each XTANDI capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will stop treatment with XTANDI if you have serious side effects.

Additional safety information can be found later in this video.

HENRY: My doctor and I have been pleased with the results of XTANDI.

Seeing where I've come from to where I am now has really put life into perspective. I savor every moment. I've seen both of my daughters get married, and I'm looking forward to whatever's next. None of that would have been possible without the support that I got from my community, my doctors, and most importantly, Katherine. I don't think I would have made it this far without her standing next to me every step of the way. I'm thankful for where I am today and excited to be with the people I love.

ANNOUNCER: Important Safety Information

What should I tell my doctor before taking XTANDI?

Tell your doctor about all your medical conditions, including if you:

• Have a history of seizures, brain injury, stroke, or brain tumors.
• Have a history of heart disease, have high blood pressure, or have abnormal amounts of fat or cholesterol in your blood (dyslipidemia).
• Are pregnant or plan to become pregnant. XTANDI can cause harm to your unborn baby and loss of pregnancy (miscarriage).
• Have a partner who is pregnant or may become pregnant.
  • Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with XTANDI and for 3 months after the last dose.
  • Males must use a condom during sex with a pregnant female.
• Are breastfeeding or plan to breastfeed. It is not known if XTANDI passes into your breast milk.
• Take other medicines. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. These include prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop any medicine without talking to your doctor.

How should I take XTANDI?

• Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. XTANDI can be taken with or without food. Swallow XTANDI capsules or tablets whole with enough water to make sure that you can swallow all of the medicine successfully. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets. Your doctor may change your dose if needed. Your doctor may also change your pill size or stop treatment if you have swallowing problems.
• Do not change or stop taking your prescribed dose of XTANDI without talking with your doctor first.
• If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment while taking XTANDI unless you have had surgery to lower the amount of testosterone in your body (surgical castration).
• If you miss a dose of XTANDI: Take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI each day.
• If you take too much XTANDI: Call your doctor or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

• Seizure. If you take XTANDI, you may be at risk of having a seizure. Avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your doctor right away if you lose consciousness or have a seizure.
• Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your doctor right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will do a test to check for PRES.
• Allergic Reactions. Allergic reactions have happened in people who take XTANDI. Stop taking XTANDI and get medical help right away if you develop swelling of the face, tongue, lip or throat.
• Heart Disease. Blockage of the arteries in the heart (ischemic heart disease) that can lead to death has happened in some people during treatment with XTANDI. Your doctor will monitor you for signs and symptoms of heart problems during your treatment. Call your doctor or go to the emergency room right away if you get chest pain or discomfort at rest or with activity or shortness of breath during your treatment with XTANDI.
• Falls and Bone Fractures. XTANDI treatment may increase your risk for falls and bone fractures. Falls were not caused by loss of consciousness or seizures. Your doctor will monitor your risks for falls and bone fractures during treatment with XTANDI.
• Swallowing Problems or Choking. Severe swallowing problems or choking, including life-threatening problems or death can happen in people during treatment with XTANDI, because of the size of the XTANDI capsules and tablets. Swallow each XTANDI capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will stop treatment with XTANDI if you have serious side effects.

The most common side effects of XTANDI include:

• Muscle and joint pain
• Feeling more tired than usual
• Hot flashes
• Constipation
• Decreased appetite
• Diarrhea
• High blood pressure
• Bleeding problems
• Falls
• Bone fractures
• Headache

XTANDI may cause fertility problems in males, which may affect the ability to father children. Talk to your doctor if you have concerns about fertility.

These are not all the possible side effects of XTANDI. For more information, talk to your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For further information, please talk to your doctor and click here for Patient Information and Full Prescribing Information for XTANDI.

BERNNIE: That's right. Hold him, hold him! Don't let him get up on you like that. Come on.

When you're breaking a horse, we have a little saying, "If you're going to be dumb, you better be tough."

Attaboy, attaboy.

The horse threw me is like, "Oh, man, that horse threw me. That hurt. Let's do this again." It's like man against beast. And with my prostate cancer, it's man against beast.

My name is Bernnie. I'm from the heart of the Mississippi Delta.

Oh, how many of them grandbabies you got now?

LES (BERNNIE'S FRIEND): Four. All boys.

BERNNIE: What I like about living in Mississippi is the people. We call it the compound. Everyone knows everybody. If you need a cup of sugar or something, you know, you just go to your sister's house or your cousin's house.

My wife, she hasn't been doing well. I've had to learn to do chores that I've never done before.

If I wash clothes and then I try to keep up with the yard or I try to keep up with myself.

Run to the ball.

I feel like if I ever stop, I won't ever start back up.

Do you remember when I got diagnosed?

LES: I do. You had lost a lot of weight, right?

BERNNIE: Yeah, I was down to 170 pounds. I lost over 50 pounds.

LES: You get down close to my size.

BERNNIE: When a horse throws you, you don't go to the doctor, you dust it off. So when I started getting sick, being the thickheaded, hardheaded, dumb tough guy that I think I am, I was just dusting it off.

It was something that I thought would go away. I didn't want to talk to nobody about it. That was my business. It wasn't nobody else's business. You know, I didn't even want my wife to know.

I would get to work and just start throwing up; I would just be soaking wet and sweat.

I was to the point I couldn't hardly pick my legs up anymore. I couldn't get my boot on. I had golfball-sized lumps that had come up on my neck.

There was a moment there where I was just scared. You know, I didn't know what to do. I didn't know who to turn to. I couldn't hide it any longer. My wife started pestering me, you know. You've got to go to the doctor. You've got to go to the doctor.

I had guys I worked with. They're like, look, we're going to put you in a truck and we're going to haul you up there ourselves. You have got to go get you some help.

And so finally, old hardhead here, I listened, and I decided to go to the doctor.

LES: You should have gone to get checked way before you did, Bernnie.

BERNNIE: Well, I should have listened to you. I realized that, but y'all know I'm hardheaded.

LES: Yeah. Like, like, like all of us.

BERNNIE: When I walked into that urology clinic that day, I looked like death sucking on a Life Saver. I mean, my eyes were sunk in, my skin was getting wrinkled up. I mean, I just, I looked like a skeleton.

And my doctors and all, they ran a PSA test on me, which came out to be very high.

And he pulled, like, six needle biopsies on me and all that come back positive.

I was diagnosed with stage four prostate cancer, and it had metastasized.

I was really shook up. I mean, my heart just dropped. This is something that don't happen to me. This is something, you know, that happens to somebody else. My doctor said surgery was off the table. Radiation was off the table. They could not do chemo. My cancer had spread.

My doctor looked at me and he said, I know about this drug XTANDI (enzalutamide). And he said, he's used this drug before.

ANNOUNCER: You're about to hear some information about XTANDI. Stay tuned for more of Bernnie's story.

What is XTANDI? XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children. XTANDI may cause serious side effects: seizure, a brain condition called PRES, allergic reactions, heart disease that can lead to death, falls and bone fractures, swallowing problems or choking that can lead to death. Your doctor will stop treatment with XTANDI if you have serious side effects. You will learn more about these and other side effects later in the video.

In a study, XTANDI has been proven to help some men delay progression.

In the same study, XTANDI has been proven to help these men live longer.

BERNNIE: I take XTANDI in the morning at the same time every day. You take four coated tablets with a glass of water and you go off about doing whatever you do.

My doctor also told me about some of the most common side effects, such as muscle and joint pain, feeling more tired than usual, and hot flashes.

AVO: You're about to hear some information about the possible serious side effects with XTANDI. Stay tuned for the rest of Bernnie's story.

Important Safety Information

Talk to your doctor or go to the emergency room right away if you experience any of these serious side effects while on XTANDI, including:

• Seizure or Sudden Loss of Consciousness. Avoid activities where loss of consciousness could cause serious harm to yourself or others.
• Posterior Reversible Encephalopathy Syndrome (PRES), a brain condition, may develop. Includes seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will check for PRES.
• Allergic Reactions. Stop taking XTANDI if you develop swelling of the face, tongue, lip or throat.
• Ischemic Heart Disease, the blockage of arteries in the heart that can lead to death. Symptoms include: chest pain, discomfort at rest or with activity, and shortness of breath. Your doctor will monitor you for signs of this disease during your treatment.
• Increased Risk of Falls and Bone Fractures. Falls were not caused by loss of consciousness (fainting) or seizures.
• Swallowing Problems or Choking. Life-threatening problems or death can happen in people during treatment because of the size of the XTANDI capsules and tablets. Swallow each capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will monitor your risks and stop XTANDI if you have serious side effects.

Additional safety information can be found later in this video.

BERNNIE: Once you have a head-turning in an event like prostate cancer, you see things through a different set of eyes.

Small things that would normally bother somebody or something, I just roll it off my back like a duck.

If I had it to do all over again, I would have gone to the doctor and try not to hide.

I've got family that cares. They're there to back me up. They're there to help me, especially my granddaughter. That girl, she'll drive five hours just to eat my BBQ grills.

GRANDDAUGHTER: Thank you.

BERNNIE: And they are delicious.

LES: But I'm really proud that you keep up your treatment.

BERNNIE: Well, I'm glad I just had a friend like you to guide me. These other men need to have that number checked.

Prostate cancer is something that affects thousands and thousands of men. There's no reason for anyone to have to go through this alone.

I talked to men in church. I talked to men in my doctor's office.

We've become a brotherhood. It's what it is. All fighting for that same battle.

If you're still listening to me, take it from this hardheaded Southerner. Don't wait. Go get yourself checked out.

AVO: Important Safety Information & Use About XTANDI

What should I tell my doctor before taking XTANDI?

Tell your doctor about all your medical conditions, including if you:

• Have a history of seizures, brain injury, stroke, or brain tumors.
• Have a history of heart disease, have high blood pressure, or have abnormal amounts of fat or cholesterol in your blood (dyslipidemia).
• Are pregnant or plan to become pregnant. XTANDI can cause harm to your unborn baby and loss of pregnancy (miscarriage).
• Have a partner who is pregnant or may become pregnant.
  • Males who have female partners who are able to become pregnant should use effective birth control (contraception) during treatment with XTANDI and for 3 months after the last dose.
  • Males must use a condom during sex with a pregnant female.
• Are breastfeeding or plan to breastfeed. It is not known if XTANDI passes into your breast milk.
• Take other medicines. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. These include prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not start or stop any medicine without talking to your doctor.

How should I take XTANDI?

• Take XTANDI exactly as your doctor tells you. Take your prescribed dose once a day, at the same time each day. XTANDI can be taken with or without food. Swallow XTANDI capsules or tablets whole with enough water to make sure that you can swallow all of the medicine successfully. Do not chew, dissolve, or open the capsules. Do not cut, crush or chew the tablets. Your doctor may change your dose if needed. Your doctor may also change your pill size or stop treatment if you have swallowing problems.
• Do not change or stop taking your prescribed dose of XTANDI without talking with your doctor first.
• If you are receiving gonadotropin-releasing hormone (GnRH) therapy, you should continue with this treatment while taking XTANDI unless you have had surgery to lower the amount of testosterone in your body (surgical castration).
• If you miss a dose of XTANDI: Take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI each day.
• If you take too much XTANDI: Call your doctor or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

• Seizure. If you take XTANDI, you may be at risk of having a seizure. Avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your doctor right away if you lose consciousness or have a seizure.
• Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your doctor right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your doctor will do a test to check for PRES.
• Allergic Reactions. Allergic reactions have happened in people who take XTANDI. Stop taking XTANDI and get medical help right away if you develop swelling of the face, tongue, lip or throat.
• Heart Disease. Blockage of the arteries in the heart (ischemic heart disease) that can lead to death has happened in some people during treatment with XTANDI. Your doctor will monitor you for signs and symptoms of heart problems during your treatment. Call your doctor or go to the emergency room right away if you get chest pain or discomfort at rest or with activity or shortness of breath during your treatment with XTANDI.
• Falls and Bone Fractures. XTANDI treatment may increase your risk for falls and bone fractures. Falls were not caused by loss of consciousness or seizures. Your doctor will monitor your risks for falls and bone fractures during treatment with XTANDI.
• Swallowing Problems or Choking. Severe swallowing problems or choking, including life-threatening problems or death can happen in people during treatment with XTANDI, because of the size of the XTANDI capsules and tablets. Swallow each XTANDI capsule or tablet whole with enough water to make sure that you can swallow all of the medicine successfully.

Your doctor will stop treatment with XTANDI if you have serious side effects.

The most common side effects of XTANDI include:

• Muscle and joint pain
• Feeling more tired than usual
• Hot flashes
• Constipation
• Decreased appetite
• Diarrhea
• High blood pressure
• Bleeding problems
• Falls
• Bone fractures
• Headache

XTANDI may cause fertility problems in males, which may affect the ability to father children. Talk to your doctor if you have concerns about fertility.

These are not all the possible side effects of XTANDI. For more information, talk to your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

For further information, please talk to your doctor and read the Patient Information and Full Prescribing Information for XTANDI.

What is XTANDI?

XTANDI (enzalutamide) is a prescription medicine used to treat men with prostate cancer that:

• no longer responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone

OR

• has not spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone, and who are at high risk of cancer spreading to other parts of the body

It is not known if XTANDI is safe and effective in females or children.