Download IconFull Prescribing Information

XTANDI is a prescription medicine used to treat men with prostate cancer that no longer responds to a medical or surgical treatment that lowers testosterone and that has spread to other parts of the body. (This is a type of advanced prostate cancer.)

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Help With Side Effects

Tips to discuss with your doctor

These tips come from organizations that focus on supporting people with cancer. The tips have not been studied with XTANDI; however, they may be able to help with prostate cancer side effects such as: weakness, feeling tired, pain, diarrhea, or hot flashes. You should always talk with your healthcare team before deciding if any of these tips are right for you.

Weakness

Drink plenty of fluids, especially water.
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Your body needs water to do its work. Talk to your healthcare team about how much water to drink each day.

Stay active.
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Try going for short walks or doing light stretching exercises. Talk with your healthcare team about other types of exercises that may help you feel better.

Get a good night’s sleep.
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If you feel tired during the day, it’s okay to rest and take a nap. Try to keep your naps short and early in the day so they don’t interfere with nighttime sleep.

Feeling tired

Try to exercise.
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Exercise can help you feel better both physically and mentally. If you decide to exercise, make sure to check with your doctor about healthy ways to add it to your routine.

Focus on relaxing.
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If you’re feeling stressed, it might help if you talk to other men living with advanced prostate cancer. Support groups can be a great place to start. You can also try doing things that can help you relax but that require little energy, like reading, listening to music, or meditating.

Stick with a consistent sleep schedule.
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Try to sleep 7 to 8 hours each night. Also, try to limit your naps to under 30 minutes. If you can, avoid foods and drinks high in caffeine at night.

Talk with your healthcare team or dietician about managing your diet.
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Work with them to create an eating plan that includes the right amount of nutrients and fluids your body needs.

Pain

Keep a pain journal to share with your healthcare team.
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Keeping a journal can help you keep track of exactly when you felt the pain, how long it lasted, and what you were doing when the pain started. Try to rate the pain on a scale of 0 to 10, with 10 being the highest. If you are having pain, make sure to talk with your healthcare team to find ways to help you.

Try using warm compresses.
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Using warm compresses may be able to help reduce pain, especially if it’s muscle-related.

Try relaxation techniques.
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Try doing things to help you relax, such as breathing exercises and meditation, to help reduce tension and pain.

Talk with your doctor about medicines that may help reduce pain.
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He or she may prescribe certain medicines to help reduce your pain.

Diarrhea*

Try to drink plenty of fluids.
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If you can, stick to mild, clear liquids, such as apple juice, water, or clear broth.

Eat smaller amounts of food, but try eating more often.
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It’s also a good idea to avoid foods that can make diarrhea worse. These include:

  • Coffee, tea, alcohol, and sweets
  • Whole-grain breads, raw vegetables, and fresh or dried fruit
  • Fried, greasy, or spicy foods
  • Milk and other dairy products

*Call your doctor if you have diarrhea for more than 24 hours, or if you have pain or cramping.

Hot flashes

Try to lower your body’s temperature.
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As a start, try wearing loose-fitting cotton clothing. You might also want to keep a fan running and your windows open—this can help circulate the air throughout your home.

Try relaxation techniques.
Relax Icon

If you can, try taking slow, deep breaths to help you relax.

Talk with your doctor or nurse about any side effects you experience and ways to help manage them.

Who is XTANDI for?

XTANDI is a prescription medicine used to treat men with prostate cancer that no longer responds to a medical or surgical treatment that lowers testosterone and that has spread to other parts of the body. (This is a type of advanced prostate cancer.)

Important Safety Information

Who should not take XTANDI? XTANDI is not for use in women. Do not take XTANDI if you are pregnant or may become pregnant. XTANDI can harm your unborn baby. It is not known if XTANDI is safe and effective in children.

Before you take XTANDI, tell your healthcare provider if you:

  • Have a history of seizures, brain injury, stroke or brain tumors.
  • Have any other medical conditions.
  • Have a partner who is pregnant or may become pregnant. Men who are sexually active with a pregnant woman must use a condom during and for 3 months after treatment with XTANDI. If your sexual partner may become pregnant, a condom and another form of birth control must be used during and for 3 months after treatment. Talk with your healthcare provider if you have questions about birth control. See "Who should not take XTANDI?"
  • Take any other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. You should not start or stop any medicine before you talk with the healthcare provider that prescribed XTANDI.

How should I take XTANDI?

  • Take XTANDI exactly as your healthcare provider tells you.
  • Take your prescribed dose of XTANDI one time a day, at the same time each day.
  • Your healthcare provider may change your dose if needed.
  • Do not change or stop taking your prescribed dose of XTANDI without talking with your healthcare provider first.
  • XTANDI can be taken with or without food.
  • Swallow XTANDI capsules whole. Do not chew, dissolve, or open the capsules.
  • If you miss a dose of XTANDI, take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI in one day.
  • If you take too much XTANDI, call your healthcare provider or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

  • Seizure.Seizure. If you take XTANDI you may be at risk of having a seizure. You should avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your healthcare provider right away if you have loss of consciousness or seizure. Your healthcare provider will stop XTANDI if you have a seizure during treatment.
  • Posterior Reversible Encephalopathy Syndrome (PRES).Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your healthcare provider right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your healthcare provider will do a test to check for PRES. Your healthcare provider will stop XTANDI if you develop PRES.

The most common side effects of XTANDI include weakness or feeling more tired than usual, back pain, decreased appetite, constipation, joint pain, diarrhea, hot flashes, upper respiratory tract infection, swelling in your hands, arms, legs, or feet, shortness of breath, muscle and bone pain, weight loss, headache, high blood pressure, dizziness, and a feeling that you or things around you are moving or spinning (vertigo).

XTANDI may cause infections, falls and injuries from falls. Tell your healthcare provider if you have signs or symptoms of an infection or if you fall.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of XTANDI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-10881-800-FDA-1088.

Please see the Full Prescribing Information for complete prescribing information.

Who is XTANDI for?

XTANDI is a prescription medicine used to treat men with prostate cancer that no longer responds to a medical or surgical treatment that lowers testosterone and that has spread to other parts of the body. (This is a type of advanced prostate cancer.)

Important Safety Information

Who should not take XTANDI? XTANDI is not for use in women. Do not take XTANDI if you are pregnant or may become pregnant. XTANDI can harm your unborn baby. It is not known if XTANDI is safe and effective in children.

Before you take XTANDI, tell your healthcare provider if you:

  • Have a history of seizures, brain injury, stroke or brain tumors.
  • Have any other medical conditions.
  • Have a partner who is pregnant or may become pregnant. Men who are sexually active with a pregnant woman must use a condom during and for 3 months after treatment with XTANDI. If your sexual partner may become pregnant, a condom and another form of birth control must be used during and for 3 months after treatment. Talk with your healthcare provider if you have questions about birth control. See "Who should not take XTANDI?"
  • Take any other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. You should not start or stop any medicine before you talk with the healthcare provider that prescribed XTANDI.

How should I take XTANDI?

  • Take XTANDI exactly as your healthcare provider tells you.
  • Take your prescribed dose of XTANDI one time a day, at the same time each day.
  • Your healthcare provider may change your dose if needed.
  • Do not change or stop taking your prescribed dose of XTANDI without talking with your healthcare provider first.
  • XTANDI can be taken with or without food.
  • Swallow XTANDI capsules whole. Do not chew, dissolve, or open the capsules.
  • If you miss a dose of XTANDI, take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI in one day.
  • If you take too much XTANDI, call your healthcare provider or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

  • Seizure.Seizure. If you take XTANDI you may be at risk of having a seizure. You should avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your healthcare provider right away if you have loss of consciousness or seizure. Your healthcare provider will stop XTANDI if you have a seizure during treatment.
  • Posterior Reversible Encephalopathy Syndrome (PRES).Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your healthcare provider right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your healthcare provider will do a test to check for PRES. Your healthcare provider will stop XTANDI if you develop PRES.

The most common side effects of XTANDI include weakness or feeling more tired than usual, back pain, decreased appetite, constipation, joint pain, diarrhea, hot flashes, upper respiratory tract infection, swelling in your hands, arms, legs, or feet, shortness of breath, muscle and bone pain, weight loss, headache, high blood pressure, dizziness, and a feeling that you or things around you are moving or spinning (vertigo).

XTANDI may cause infections, falls and injuries from falls. Tell your healthcare provider if you have signs or symptoms of an infection or if you fall.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of XTANDI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see the Full Prescribing Information for complete prescribing information.

Important Safety Information

Who should not take XTANDI? XTANDI is not for use in women. Do not take XTANDI if you are pregnant or may become pregnant. XTANDI can harm your unborn baby. It is not known if XTANDI is safe and effective in children.

Before you take XTANDI, tell your healthcare provider if you:

  • Have a history of seizures, brain injury, stroke or brain tumors.
  • Have any other medical conditions.
  • Have a partner who is pregnant or may become pregnant. Men who are sexually active with a pregnant woman must use a condom during and for 3 months after treatment with XTANDI. If your sexual partner may become pregnant, a condom and another form of birth control must be used during and for 3 months after treatment. Talk with your healthcare provider if you have questions about birth control. See "Who should not take XTANDI?"
  • Take any other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements. XTANDI may affect the way other medicines work, and other medicines may affect how XTANDI works. You should not start or stop any medicine before you talk with the healthcare provider that prescribed XTANDI.

How should I take XTANDI?

  • Take XTANDI exactly as your healthcare provider tells you.
  • Take your prescribed dose of XTANDI one time a day, at the same time each day.
  • Your healthcare provider may change your dose if needed.
  • Do not change or stop taking your prescribed dose of XTANDI without talking with your healthcare provider first.
  • XTANDI can be taken with or without food.
  • Swallow XTANDI capsules whole. Do not chew, dissolve, or open the capsules.
  • If you miss a dose of XTANDI, take your prescribed dose as soon as you remember that day. If you miss your daily dose, take your prescribed dose at your regular time the next day. Do not take more than your prescribed dose of XTANDI in one day.
  • If you take too much XTANDI, call your healthcare provider or go to the nearest emergency room right away. You may have an increased risk of seizure if you take too much XTANDI.

What are the possible side effects of XTANDI?

XTANDI may cause serious side effects including:

  • Seizure.Seizure. If you take XTANDI you may be at risk of having a seizure. You should avoid activities where a sudden loss of consciousness could cause serious harm to yourself or others. Tell your healthcare provider right away if you have loss of consciousness or seizure. Your healthcare provider will stop XTANDI if you have a seizure during treatment.
  • Posterior Reversible Encephalopathy Syndrome (PRES).Posterior Reversible Encephalopathy Syndrome (PRES). If you take XTANDI you may be at risk of developing a condition involving the brain called PRES. Tell your healthcare provider right away if you have a seizure or quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blurred vision or other visual problems. Your healthcare provider will do a test to check for PRES. Your healthcare provider will stop XTANDI if you develop PRES.

The most common side effects of XTANDI include weakness or feeling more tired than usual, back pain, decreased appetite, constipation, joint pain, diarrhea, hot flashes, upper respiratory tract infection, swelling in your hands, arms, legs, or feet, shortness of breath, muscle and bone pain, weight loss, headache, high blood pressure, dizziness, and a feeling that you or things around you are moving or spinning (vertigo).

XTANDI may cause infections, falls and injuries from falls. Tell your healthcare provider if you have signs or symptoms of an infection or if you fall.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of XTANDI. For more information, ask your healthcare provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see the Full Prescribing Information for complete prescribing information.